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Linezolid fluoxetine — GPhC CRA MCQ

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ModerateDrug InteractionsLinezolid fluoxetineGPhC CRA

A patient taking fluoxetine is prescribed linezolid for a resistant infection. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: E — Linezolid with fluoxetine can increase risk of serotonin syndrome

Linezolid has monoamine oxidase inhibiting properties and can interact with serotonergic drugs. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF