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Clozapine constipation — GPhC CRA MCQ

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EasyAdverse Drug Reactions and Drug SafetyClozapine constipationGPhC CRA

A patient taking clozapine has severe constipation, abdominal pain and vomiting. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Refer urgently because clozapine-related gastrointestinal hypomotility can be serious

Clozapine can cause life-threatening gastrointestinal hypomotility. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; MHRA