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Gabapentin and opioid — GPhC CRA MCQ

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ModerateCNS TherapeuticsGabapentin and opioidGPhC CRA

A frail older woman with COPD takes gabapentin and is newly prescribed oxycodone. What is the most important interaction to flag?

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Correct answer: D — Gabapentin with opioids can increase sedation and respiratory depression risk

Gabapentinoids and opioids have additive central nervous system depressant effects. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; MHRA