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Clopidogrel and omeprazole — GPhC CRA MCQ

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HardCardiovascular TherapeuticsClopidogrel and omeprazoleGPhC CRA

A patient after coronary stenting is prescribed clopidogrel and omeprazole for gastroprotection. What is the most appropriate alternative?

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Correct answer: A — Discuss switching omeprazole to lansoprazole or pantoprazole

Omeprazole can reduce clopidogrel activation through CYP2C19 inhibition. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; NICE CKS