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Semaglutide nausea — GPhC CRA MCQ

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HardEndocrine TherapeuticsSemaglutide nauseaGPhC CRA

A patient with end-of-dose motor fluctuations is starting opicapone alongside co-careldopa taken five times daily. Which administration plan matches the Ongentys SmPC?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Take opicapone once daily at bedtime, at least one hour before or after a levodopa combination

Option B is correct: opicapone is a once-daily bedtime medicine separated by at least one hour from levodopa combinations. Option E combines it with levodopa and protein. Option C incorrectly divides the dose. Option A turns regular adjunctive treatment into as-required use. Option D gives repeated daily opicapone doses and removes the required separation; levodopa may instead need clinician-led adjustment because opicapone enhances its effects.

Reference: Ongentys SmPC: https://www.medicines.org.uk/emc/product/7386/smpc