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Bupropion tramadol — GPhC CRA MCQ

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EasyDrug InteractionsBupropion tramadolGPhC CRA

A patient prescribed bupropion for smoking cessation also takes tramadol and has a past seizure history. What is the most important interaction to flag?

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Correct answer: C — Bupropion and tramadol can both lower seizure threshold

The combination is concerning because both medicines can increase seizure risk. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF