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Lithium ibuprofen — GPhC CRA MCQ

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EasyDrug InteractionsLithium ibuprofenGPhC CRA

A patient stabilised on lithium asks to buy ibuprofen for a sports injury. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: D — Ibuprofen can increase lithium levels and toxicity risk

NSAIDs can reduce renal lithium clearance and increase lithium concentrations. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF