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SGLT2 ketoacidosis — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetySGLT2 ketoacidosisGPhC CRA

A patient taking empagliflozin has nausea, abdominal pain and rapid breathing despite near-normal glucose after fasting. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Refer urgently for possible euglycaemic diabetic ketoacidosis

SGLT2 inhibitors can cause ketoacidosis with relatively normal blood glucose. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; MHRA