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St John's wort sertraline — GPhC CRA MCQ

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ModerateDrug InteractionsSt John's wort sertralineGPhC CRA

A patient taking sertraline asks to buy St John's wort for low mood. What is the most important interaction to flag?

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Correct answer: B — St John's wort can interact with sertraline and increase serotonergic adverse effect risk

St John's wort has serotonergic effects and also induces drug-metabolising enzymes. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF