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Eplerenone and clarithromycin — GPhC CRA MCQ

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EasyCardiovascular TherapeuticsEplerenone and clarithromycinGPhC CRA

A patient taking eplerenone after myocardial infarction is prescribed clarithromycin for infection. What is the most important interaction to flag?

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Correct answer: A — Clarithromycin can increase eplerenone exposure and hyperkalaemia risk

Eplerenone is affected by CYP3A4 inhibitors and potassium risk is clinically relevant. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF