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Grapefruit simvastatin — GPhC CRA MCQ

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ModerateDrug InteractionsGrapefruit simvastatinGPhC CRA

A patient taking simvastatin drinks grapefruit juice every morning. What would you advise the patient?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Grapefruit juice can increase simvastatin exposure and myopathy risk

Grapefruit inhibits intestinal CYP3A4 and increases simvastatin concentrations. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF