Carbimazole warning — GPhC CRA MCQ
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Correct answer: C — Immediate carbimazole cessation, urgent clinical assessment and an FBC before reconsideration
Fever, sore throat and mouth ulcers are warning symptoms of carbimazole-associated neutropenia or agranulocytosis. The medicine should be stopped immediately and urgent medical assessment with a full blood count arranged; restart must await an appropriate clinical decision. Thyroid tests, brief dose omission, symptom treatment or delayed review do not address a potentially life-threatening blood dyscrasia, which can occur early.
Reference: SPS: carbimazole monitoring. https://sps.nhs.uk/monitorings/carbimazole-monitoring/