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Clarithromycin statin — GPhC CRA MCQ

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HardInfectionsClarithromycin statinGPhC CRA

A patient taking apixaban is prescribed itraconazole capsules for a fungal infection. What is the main interaction concern?

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Correct answer: A — Strong CYP3A4 and P-glycoprotein inhibition may raise apixaban exposure

Itraconazole strongly inhibits CYP3A4 and P-glycoprotein and can substantially increase apixaban exposure and bleeding risk. The prescription requires indication, renal function and alternative-treatment review using current product and specialist guidance.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment