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Donepezil syncope — GPhC CRA MCQ

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EasyCNS TherapeuticsDonepezil syncopeGPhC CRA

An older man taking donepezil and bisoprolol reports fainting episodes. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: B — Refer for assessment because donepezil and beta-blockade may contribute to bradycardia or syncope

Donepezil can cause bradycardia and syncope, particularly with rate-limiting medicines. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF