Pioglitazone heart failure — GPhC CRA MCQ
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Correct answer: A — Withhold supply and urgently clarify the prescription because pioglitazone-related fluid retention can worsen heart failure
Pioglitazone can cause fluid retention and should be avoided in heart failure; worsening oedema strengthens the need to clarify before exposure. A short supply or dose reduction does not neutralise the risk, and compression advice would delay assessment. The pharmacist cannot substitute a different prescription medicine under the existing prescription without a lawful prescribing or amendment route.
Reference: NICE NG28: type 2 diabetes in adults — initial medicines. https://www.nice.org.uk/guidance/NG28/chapter/initial-medicines