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Ciprofloxacin tizanidine — GPhC CRA MCQ

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ModerateDrug InteractionsCiprofloxacin tizanidineGPhC CRA

A patient taking tizanidine presents a prescription for ciprofloxacin and feels light-headed at baseline. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Ciprofloxacin can markedly increase tizanidine exposure and hypotension risk

Ciprofloxacin inhibits CYP1A2 and can substantially increase tizanidine levels. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF