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Sertraline and tramadol — GPhC CRA MCQ

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ModerateCNS TherapeuticsSertraline and tramadolGPhC CRA

A patient taking sertraline asks to use tramadol capsules from a relative for dental pain. What is the most important interaction to flag?

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Correct answer: C — Sertraline with tramadol increases risk of serotonin syndrome and seizures

Tramadol is serotonergic and lowers seizure threshold; using another person's prescription is unsafe. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF; MEP