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Methotrexate NSAID — GPhC CRA MCQ

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EasyDrug InteractionsMethotrexate NSAIDGPhC CRA

A patient taking weekly methotrexate asks to buy naproxen and has mild renal impairment. What is the most appropriate action?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: C — Naproxen can increase methotrexate toxicity risk, particularly with renal impairment

NSAIDs can reduce methotrexate elimination and increase toxicity risk. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF