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Simvastatin with amlodipine — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSimvastatin with amlodipineGPhC CRA

A prescription requests simvastatin 40 mg nightly for a patient taking amlodipine 10 mg daily. The patient has no recent muscle symptoms. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Amlodipine increases simvastatin exposure and the simvastatin dose should not exceed 20 mg daily

The interaction increases the risk of statin-associated myopathy and requires dose or statin review. In this scenario, the pharmacist should prioritise safe supply, appropriate counselling and timely referral or clarification where needed. This is the single best answer because the other options would either delay assessment, ignore a clinically significant risk, or create an unsafe legal or professional outcome.

Reference: BNF