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ACE inhibitor in pregnancy — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsACE inhibitor in pregnancyGPhC CRA

A patient taking lisinopril for hypertension tells you she has a positive pregnancy test. She is well and asks whether she can continue her tablets until the GP appointment next week. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Advise urgent prescriber contact to stop lisinopril and switch to a pregnancy-suitable antihypertensive

ACE inhibitors should be avoided in pregnancy because of fetal toxicity risk, particularly later in pregnancy. The patient needs prompt prescriber review to stop lisinopril and select a more suitable antihypertensive such as labetalol, nifedipine or methyldopa depending on clinical factors. The pharmacist should not leave the issue until routine review.

Reference: BNF; NICE CKS