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Amiodarone and warfarin — GPhC CRA MCQ

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HardDrug InteractionsAmiodarone and warfarinGPhC CRA

A patient taking warfarin for a mechanical valve is newly prescribed amiodarone. The anticoagulation clinic is not aware yet. What is the most important interaction to flag?

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Correct answer: C — Increased warfarin effect requiring INR monitoring and possible dose adjustment

Amiodarone can increase the anticoagulant effect of warfarin, and the interaction may develop over time. INR monitoring and dose adjustment may be needed under anticoagulation clinic supervision. The pharmacist should communicate the new medicine to the relevant team. The patient should be counselled on bleeding symptoms.

Reference: BNF