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Linezolid and SSRI — GPhC CRA MCQ

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HardDrug InteractionsLinezolid and SSRIGPhC CRA

A patient taking sertraline 100 mg daily is prescribed linezolid for a resistant skin infection. The prescriber asks what risk should be considered. What is the most important interaction to flag?

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Correct answer: C — Serotonin syndrome due to monoamine oxidase inhibition by linezolid

Linezolid has monoamine oxidase inhibitor activity and can interact with serotonergic medicines such as SSRIs. Serotonin syndrome is potentially serious and requires prescriber assessment and monitoring or an alternative plan. Symptoms include agitation, confusion, sweating, tremor and diarrhoea. The interaction is not a simple absorption problem.

Reference: https://www.pharmacyregulation.org/students-and-trainees/pharmacist-education-and-training/registration-assessment