skip to main content

PPI and clopidogrel selection — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateGI TherapeuticsPPI and clopidogrel selectionGPhC CRA

A patient taking clopidogrel needs gastroprotection after a previous ulcer. The GP has prescribed omeprazole and asks whether this is the best option. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Suggest lansoprazole or pantoprazole as a preferred PPI with clopidogrel

Omeprazole and esomeprazole can reduce activation of clopidogrel via CYP2C19 inhibition. When a PPI is needed with clopidogrel, alternatives such as lansoprazole or pantoprazole are commonly preferred. The antiplatelet should not be stopped without prescriber review. The need for gastroprotection remains clinically relevant because of previous ulcer history.

Reference: BNF; NICE CKS