Colchicine renal impairment — GPhC CRA MCQ
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Correct answer: E — Contact the prescriber urgently because toxicity risk is high with renal impairment and clarithromycin
Colchicine has a narrow therapeutic index and toxicity risk rises with renal impairment. Clarithromycin can increase colchicine exposure and the combination can be dangerous. The pharmacist should contact the prescriber before supply. Diarrhoea may be an early sign of toxicity rather than a target effect.
Reference: BNF; NICE CKS