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Sildenafil and alpha-blocker — GPhC CRA MCQ

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ModerateDrug InteractionsSildenafil and alpha-blockerGPhC CRA

A patient taking doxazosin modified-release for benign prostatic enlargement asks to buy sildenafil for erectile dysfunction. What is the most important interaction to flag?

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Correct answer: A — Increased risk of symptomatic hypotension

Sildenafil and alpha-blockers can both lower blood pressure. The combination can cause dizziness, postural hypotension or syncope, particularly when starting treatment or increasing doses. The pharmacist should check suitability, cardiovascular status and timing advice. Nitrate use must also be excluded.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-22