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Antibiotic dose in renal impairment — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentAntibiotic dose in renal impairmentGPhC CRA

A prescription for amoxicillin 1 g three times daily is presented for an 84-year-old patient with eGFR 12 mL/min/1.73 m2. The indication is lower respiratory infection. What is the most appropriate action?

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Correct answer: A — Check whether the dose is appropriate for renal function before dispensing

Renal impairment can require dose adjustment for many antibiotics, including amoxicillin at severe impairment levels. The pharmacist should check renal dosing guidance and liaise with the prescriber if needed. Independent dose alteration without agreement is inappropriate. Adding another antibiotic is outside the pharmacist's role and may increase harm.

Reference: BNF; NICE CKS