Trimethoprim with ACE inhibitor — GPhC CRA MCQ
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Correct answer: C — The combination can increase the risk of hyperkalaemia
Trimethoprim can raise serum potassium, and the risk is increased with ACE inhibitors, potassium-sparing diuretics and renal impairment. This patient has several risk factors for serious hyperkalaemia. The prescription should be queried and monitoring or an alternative considered.
Reference: BNF