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Penicillin allergy and cephalexin — GPhC CRA MCQ

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ModerateInfectionsPenicillin allergy and cephalexinGPhC CRA

A patient prescribed cefalexin for cellulitis tells you he developed facial swelling and breathing difficulty after amoxicillin as a child. What is the most appropriate alternative?

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Correct answer: D — Withhold supply and contact the prescriber about severe beta-lactam allergy history

Facial swelling and breathing difficulty suggest a serious immediate hypersensitivity reaction. Cefalexin is a beta-lactam and may not be appropriate without prescriber assessment. The pharmacist should contact the prescriber for an alternative if needed. Antihistamine cover does not make dispensing safe in a high-risk allergy history.

Reference: BNF; NICE CKS