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Citalopram and NSAID bleeding — GPhC CRA MCQ

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ModerateDrug InteractionsCitalopram and NSAID bleedingGPhC CRA

A patient taking citalopram 20 mg daily asks to buy ibuprofen for back pain. He has a previous history of gastric ulcer. What is the most important interaction to flag?

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Correct answer: C — Increased gastrointestinal bleeding risk

SSRIs can increase bleeding risk, and NSAIDs further increase gastrointestinal bleeding risk. Previous ulcer disease makes the concern more significant. A safer analgesic strategy and gastroprotection assessment may be needed. The interaction is not a loss of antidepressant efficacy.

Reference: BNF; NICE CKS