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Simvastatin with amlodipine — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsSimvastatin with amlodipineGPhC CRA

A prescription is received for simvastatin 40mg at night. The patient also takes amlodipine 10mg once daily for hypertension. What is the most important interaction to flag?

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Correct answer: B — Amlodipine can increase simvastatin exposure and myopathy risk

Amlodipine increases exposure to simvastatin, increasing the risk of myopathy and rhabdomyolysis. The usual maximum recommended simvastatin dose with amlodipine is lower than 40mg daily. The prescription should be queried and a safer statin strategy considered.

Reference: BNF