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Smoking cessation and theophylline — GPhC CRA MCQ

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HardRespiratory TherapeuticsSmoking cessation and theophyllineGPhC CRA

A patient taking theophylline MR is starting varenicline and plans to stop smoking this week. Their theophylline level was previously stable. What monitoring is required?

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Correct answer: E — Monitor for increased theophylline levels after smoking cessation

Smoking induces CYP1A2, increasing theophylline clearance. When a patient stops smoking, theophylline levels may rise and toxicity can occur. The prescriber should review the dose and arrange monitoring where appropriate.

Reference: BNF