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Statin rhabdomyolysis symptoms — GPhC CRA MCQ

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ModerateAdverse Drug Reactions and Drug SafetyStatin rhabdomyolysis symptomsGPhC CRA

A patient taking atorvastatin reports severe muscle pain, weakness and dark urine after starting clarithromycin from an out-of-hours clinic. What monitoring is required?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Advise urgent medical assessment for possible rhabdomyolysis

Severe muscle pain, weakness and dark urine can indicate rhabdomyolysis. Clarithromycin can increase statin exposure and precipitate toxicity, especially with some statins. The patient needs urgent assessment including creatine kinase and renal function. Continuing treatment without review could be dangerous.

Reference: BNF; NICE CKS