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Antidepressant discontinuation — GPhC CRA MCQ

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ModerateCNS TherapeuticsAntidepressant discontinuationGPhC CRA

A patient taking paroxetine 20 mg daily says she feels well and plans to stop it tomorrow because she dislikes taking tablets. What would you advise the patient?

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Correct answer: E — Discuss gradual withdrawal and advise prescriber review before stopping

Paroxetine is associated with discontinuation symptoms if stopped abruptly. Withdrawal should usually be gradual and planned with the prescriber, taking relapse risk into account. Alternate-day dosing can cause fluctuating exposure and is not a universal solution. St John's wort has interaction risks and is not appropriate as a substitute.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-21