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Domperidone cardiac risk — GPhC CRA MCQ

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HardGI TherapeuticsDomperidone cardiac riskGPhC CRA

A 74-year-old patient asks for domperidone for nausea. He takes amiodarone and has a history of heart failure. What is the most appropriate alternative?

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Correct answer: A — Avoid domperidone and refer or suggest prescriber review because of cardiac risk

Domperidone is associated with QT prolongation and serious cardiac adverse effects, particularly in older patients and those with cardiac disease. Amiodarone also prolongs QT and increases concern. The patient should be referred for assessment and a safer antiemetic plan. Duration and dose should be limited when domperidone is used.

Reference: BNF; MHRA Drug Safety Update