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Methotrexate weekly dosing — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsMethotrexate weekly dosingGPhC CRA

A prescription for methotrexate 2.5 mg tablets reads 'take 6 tablets daily' for rheumatoid arthritis. The patient says she normally takes it on Mondays. What is the most appropriate action?

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Correct answer: C — Withhold supply and urgently clarify because methotrexate for rheumatoid arthritis is usually weekly

Methotrexate dosing errors can be fatal, and low-dose methotrexate for rheumatoid arthritis is normally taken once weekly. A daily direction is a critical safety concern and must be clarified before supply. Verbal correction while labelling daily would be unsafe. Tablet strength changes can also increase error risk and require careful prescribing.

Reference: BNF; NICE CKS