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Nitrofurantoin renal function — GPhC CRA MCQ

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ModerateInfectionsNitrofurantoin renal functionGPhC CRA

A 79-year-old woman is prescribed nitrofurantoin 100 mg modified-release twice daily for lower UTI. Her recent eGFR is 32 mL/min/1.73 m2. What is the most appropriate alternative?

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Correct answer: B — Query appropriateness and discuss an alternative or short-course suitability with the prescriber

Nitrofurantoin efficacy and safety are affected by renal function. At reduced eGFR, use may be inappropriate or limited to specific short-course circumstances depending on guidance and clinical context. The pharmacist should clarify the plan with the prescriber. Independent dose changes or substitution are not appropriate.

Reference: BNF; NICE CKS