A woman at 9 weeks’ gestation has a lower UTI. Culture shows an organism susceptible to nitrofurantoin and cefalexin; eGFR is 78 mL/min/1.73 m². A

Question

A woman at 9 weeks’ gestation has a lower UTI. Culture shows an organism susceptible to nitrofurantoin and cefalexin; eGFR is 78 mL/min/1.73 m². A prescription is issued for trimethoprim. What is the best intervention?

Accepted Answer

Contact the prescriber for a susceptible pregnancy option such as nitrofurantoin; avoid first-trimester trimethoprim

Answer

Substitute ciprofloxacin because culture susceptibility permits a pharmacist to change the prescribed POM

Answer

Dispense trimethoprim because folate antagonism becomes relevant only after fetal neural-tube closure

Answer

Delay antimicrobial treatment until a repeat culture after 12 weeks confirms persistent bacteriuria

Answer

Dispense trimethoprim and advise stopping folic acid to avoid masking treatment-related blood changes

Trimethoprim in pregnancy — GPhC CRA MCQ

A woman at 9 weeks’ gestation has a lower UTI. Culture shows an organism susceptible to nitrofurantoin and cefalexin; eGFR is 78 mL/min/1.73 m². A prescription is issued for trimethoprim. What is the best intervention?