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NSAID acute kidney injury risk — GPhC CRA MCQ

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ModerateRenal and Hepatic ImpairmentNSAID acute kidney injury riskGPhC CRA

A patient with chronic kidney disease stage 3 and hypertension asks to buy ibuprofen for back pain. He takes ramipril and bendroflumethiazide. What is the most appropriate alternative?

Educational content. Not a substitute for clinical judgement or local policy.

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Correct answer: A — Avoid ibuprofen and recommend a safer analgesic approach or prescriber review

NSAIDs can precipitate acute kidney injury, particularly in chronic kidney disease and with ACE inhibitors and diuretics. This combination is clinically important even with short courses in higher-risk patients. A safer analgesic option and prescriber review should be considered. Stopping prescribed antihypertensives without review is unsafe.

Reference: BNF; NICE CKS