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Sildenafil and nitrates — GPhC CRA MCQ

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HardCardiovascular TherapeuticsSildenafil and nitratesGPhC CRA

A patient using glyceryl trinitrate spray for angina asks to buy sildenafil. He says the angina has been stable for several months. What is the most important interaction to flag?

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Correct answer: A — Sildenafil with nitrates can cause profound hypotension

PDE5 inhibitors and nitrates both increase nitric oxide mediated vasodilation. The combination can cause severe hypotension and is contraindicated. The patient should be advised not to use sildenafil and to seek prescriber review for erectile dysfunction options.

Reference: BNF