skip to main content

Rifampicin and oral contraception — GPhC CRA MCQ

Instant feedback + full explanation. One question, done properly.

ModerateDrug InteractionsRifampicin and oral contraceptionGPhC CRA

A patient using a combined oral contraceptive starts rifampicin for latent tuberculosis. She asks whether her pill will still work. What is the most important interaction to flag?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Reduced contraceptive efficacy due to enzyme induction

Rifampicin is a potent enzyme inducer and can reduce exposure to hormonal contraceptives. The patient needs advice about a method not affected by enzyme induction, such as a copper IUD or appropriate specialist-recommended alternatives. Additional precautions may be required during and after rifampicin. This is an important pregnancy-prevention counselling point.

Reference: BNF; FSRH