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C. difficile risk with broad-spectrum antibiotics — GPhC CRA MCQ

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HardInfectionsC. difficile risk with broad-spectrum antibioticsGPhC CRA

An 82-year-old patient prescribed co-amoxiclav develops watery diarrhoea 6 times daily after 5 days of treatment. She feels weak and has abdominal cramps. What is the most appropriate alternative?

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Correct answer: E — Advise urgent medical assessment for possible antibiotic-associated colitis

Frequent watery diarrhoea in an older patient on broad-spectrum antibiotics raises concern for Clostridioides difficile infection or antibiotic-associated colitis. The patient needs urgent clinical assessment, hydration advice and review of the antibiotic. Antimotility medicines can be harmful in suspected infective colitis. Delayed review may increase risk of complications.

Reference: NICE CKS; BNF