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ACE inhibitor angioedema — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetyACE inhibitor angioedemaGPhC CRA

A patient taking ramipril develops swelling of the lips and tongue with a hoarse voice. He asks whether an antihistamine will be enough. What is the most appropriate action?

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Correct answer: A — Advise immediate emergency assessment for suspected angioedema

ACE inhibitors can cause angioedema, which may threaten the airway. Lip and tongue swelling with voice change requires emergency assessment. Antihistamines may not be sufficient, particularly for bradykinin-mediated angioedema. Future ACE inhibitor use should be reviewed by a prescriber.

Reference: BNF; NICE CKS