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Clopidogrel with proton pump inhibitor — GPhC CRA MCQ

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ModerateCardiovascular TherapeuticsClopidogrel with proton pump inhibitorGPhC CRA

A patient taking clopidogrel after a TIA is prescribed omeprazole for dyspepsia. They have no history of GI bleeding. What is the most important interaction to flag?

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Correct answer: D — Omeprazole can reduce activation and effectiveness of clopidogrel

Omeprazole and esomeprazole can inhibit CYP2C19 and reduce conversion of clopidogrel to its active metabolite. If gastric protection is required, another PPI with lower interaction potential is usually preferred. The prescription should be reviewed with the prescriber.

Reference: BNF; NICE CKS