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NSAID with anticoagulant — GPhC CRA MCQ

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ModerateDrug InteractionsNSAID with anticoagulantGPhC CRA

A patient taking apixaban for atrial fibrillation asks to buy naproxen for a painful shoulder after gardening. What is the most important interaction to flag?

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Correct answer: A — Increased bleeding risk from combining NSAID and anticoagulant

NSAIDs such as naproxen increase gastrointestinal bleeding risk and can add to anticoagulant-related bleeding. A safer analgesic option should be considered and the patient referred if pain is severe or persistent. The pharmacist should ask about bleeding history and other risk factors. The interaction is pharmacodynamic rather than a gut-binding effect.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-20