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Digoxin and amiodarone — GPhC CRA MCQ

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HardDrug InteractionsDigoxin and amiodaroneGPhC CRA

A patient taking digoxin for atrial fibrillation is newly started on amiodarone. She reports nausea and blurred vision a week later. What is the most important interaction to flag?

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Correct answer: B — Increased digoxin concentration and toxicity risk

Amiodarone can increase digoxin concentrations and toxicity risk. Nausea, visual disturbance and arrhythmia symptoms may indicate digoxin toxicity. The prescriber should be contacted urgently for assessment, possible level measurement and dose adjustment. Older patients and renal impairment increase concern.

Reference: BNF