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Theophylline and ciprofloxacin — GPhC CRA MCQ

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HardRespiratory TherapeuticsTheophylline and ciprofloxacinGPhC CRA

A patient taking theophylline MR 300mg twice daily is prescribed ciprofloxacin for a chest infection. They have a history of palpitations. What is the most important interaction to flag?

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Correct answer: E — Ciprofloxacin can increase theophylline levels and toxicity risk

Ciprofloxacin can inhibit theophylline metabolism, increasing the risk of nausea, tachycardia, arrhythmias and seizures. The interaction is clinically important, particularly in a patient with palpitations. Prescriber review and alternative antibiotic consideration are appropriate.

Reference: https://www.pharmacyregulation.org/registration-assessment#stage-8-order-19