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DMARD live vaccines — GPhC CRA MCQ

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HardMusculoskeletal TherapeuticsDMARD live vaccinesGPhC CRA

A patient receiving adalimumab asks for yellow-fever vaccine before travel and also needs inactivated hepatitis A vaccine. Which statement is correct?

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Correct answer: BWithhold yellow-fever vaccine and give hepatitis A vaccine now

The adalimumab SmPC permits concurrent vaccination except for live vaccines. Yellow-fever vaccine is live, so specialist travel and treating-team advice is required about timing, destination risk or a waiver/alternative plan. Hepatitis A vaccine is inactivated and may generally be administered, although immune response can be reduced. Route of administration does not remove the live-vaccine risk.

Reference: Humira Summary of Product Characteristics: https://www.medicines.org.uk/emc/product/9678/smpc