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MAOI and decongestant — GPhC CRA MCQ

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HardCNS TherapeuticsMAOI and decongestantGPhC CRA

A patient taking phenelzine asks to buy pseudoephedrine tablets for nasal congestion. He says saline spray has not helped and he needs something stronger. What is the most important interaction to flag?

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Correct answer: E — Risk of hypertensive crisis due to sympathomimetic interaction

Monoamine oxidase inhibitors can interact dangerously with sympathomimetics such as pseudoephedrine. The interaction can cause a marked hypertensive response and should be avoided. A non-sympathomimetic option and medical review may be safer depending on severity. The pharmacist should check the patient's full medicine history before recommending over-the-counter cold remedies.

Reference: BNF