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SJS/TEN warning — GPhC CRA MCQ

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HardAdverse Drug Reactions and Drug SafetySJS/TEN warningGPhC CRA

A patient who recently started allopurinol presents with a painful widespread rash, mouth ulcers and fever. What is the most appropriate action?

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Correct answer: A — Advise immediate emergency medical assessment for possible severe cutaneous adverse reaction

Painful rash with mucosal involvement and fever suggests a possible severe cutaneous adverse reaction such as Stevens-Johnson syndrome or toxic epidermal necrolysis. This is a medical emergency. Allopurinol is a recognised trigger. Symptomatic pharmacy treatment must not delay urgent assessment.

Reference: BNF; MHRA Drug Safety Update