Benzodiazepine short-term use — GPhC CRA MCQ

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HardCNS TherapeuticsBenzodiazepine short-term useGPhC CRA

Morphine oral solution 10 mg/5 mL is prescribed at 7.5 mg every four hours when required, with a maximum of six doses daily, for seven days. What volume is needed if every permitted dose is used?

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Correct answer: E — 157.5 mL

The solution contains 2 mg/mL, so 7.5 mg requires 3.75 mL. Six doses daily for seven days is 42 doses; 42 × 3.75 mL = 157.5 mL, making Option E correct. Option A uses 2.5 mL per dose. Option C omits one daily dose. Option B uses an incorrect 3.214-mL dose. Option D rounds each 3.75-mL dose down before calculating the total.

Reference: Morphine oral solution SmPC: https://www.medicines.org.uk/emc/product/3427/smpc; GPhC framework: https://assets.pharmacyregulation.org/files/2025-09/Common-Registration-Assessment-framework-for-sittings-in-2026.pdf